Okeechobee, Florida: County courthouse, listed in A Guide to Florida's Historic Architecture. – Ebyabe, CC BY-SA 3.0 – Wikimedia Commons Okeechobee County is located in Florida. The region is located on the body of water Lake Okeechobee. About 39,469 people live here. Between 2010 and 2020, the population declined from 39,996 to 39,644. The area covers about 2,309.0 square kilometers. The region is divided into 1 Municipalities. The region was founded in 1915. The name originates from Lake Okeechobee (freshwater lake) Okeechobee County is county in Florida, United States. More information at www.co.okeechobee.fl.us.