Clay County Courthouse in Clay Center, Nebraska, seen from the northwest. The building was designed in Beaux-Arts style by architect William F. Gernandt; the cornerstone was laid in 1918. The courthouse is listed in the National Register of Historic Places. – Ammodramus, Public domain – Wikimedia Commons Clay County is located in Nebraska. About 6,104 people live here (as of 2020). Between 2010 and 2020, the population declined from 6,542 to 6,104. The area covers about 1,485.0 square kilometers. The region is divided into 10 Municipalities. The region was founded in 1871. The name originates from Henry Clay (American politician from Kentucky) Clay County is county in Nebraska, United States. More information at www.claycounty.ne.gov.