US Highway 281 in White Swan Township, South Dakota

US Highway 281 in Charles Mix County is a two-lane main road (Road number US 18;US 281). It runs in a north-south direction and crosses East US Highway 18, SD Highway 50, A Street, South 3rd Avenue, Pickstown Avenue, 293rd Street, 294th Street, 295th Street, Fish Tail Drive, 296th Street, 382nd Avenue and 297th Street. It connects Lake Andes, Pickstown and White Swan Township. This street is part of the highways 281, 18 and Lewis and Clark National Historic Trail Auto Tour Route. US Highway 281 also exists in Kennedy Township.