221st Street in Floyd Township, South Dakota

221st Street in Sanborn County is an unpaved unclassified road. It runs in an east-west direction and crosses 394th Avenue, 395th Avenue, 396th Avenue, 397th Avenue, 398th Avenue, 399th Avenue, SD Highway 37, 401st Avenue, 402nd Avenue, 403rd Avenue, 404th Avenue and 405th Avenue. It connects Jackson Township, Floyd Township and Warren Township.