South Main Street in Saint Charles, MO 63303

South Main Street in Saint Charles, MO 63303 (Saint Charles County) is a local road. It runs in a northeast-southwest direction starting from North Main Street and crosses Jefferson Street, Madison Street, First Capitol Drive, Jackson Street, Tompkins Street, Pike Street, Perry Street, Water Street, McDonough Street, Boone's Lick Road and Reservoir Avenue. It connects Saint Charles and Saint Charles County. South Main Street also exists in Scott City, Windsor, Monroe City, Excelsior Springs and Kansas City.